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Hyperkeratosis – Phrynoderma & Other Hyperkeratosis


  • What is Hyperkeratosis
  • Keratosis Pilaris
  • Keratosis Pilaris Alba
  • Keratosis Pilaris Rubra
  • Hyperkeratosis
  • Lotion for Keratosis Pilaris Treatment

Hyperkeratosis – Follicular Keratosis – Phrynoderma

Follicular hyperkeratosis is a skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules whose openings are often closed with a white plug of sebum.

Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology of follicular hyperkeratosis. Called also phrynoderma.

Phrynoderma is a form of follicular hyperkeratosis that is associated with nutritional deficiencies. It is endemic to poor populations but is rare in developed countries.

The term “phrynoderma” was coined by Nicholls in 1933 to describe the “toad-like” appearance of the skin of undernourished labourers. This form of dermatosis can be caused by isolated deficiencies of vitamins A, B complex, C and E.

Adjunctive symptoms, such as cheilitis, glossitis, blepharitis, night blindness, diarrhea, muscle weakness and neuritis, may develop when hypovitaminosis A is predominant relative to other vitamin deficiencies.

In developed countries, phrynoderma most often occurs as a result of mal-absorption due to surgical or medical causes, such as small-bowel bypass surgery, colectomy and pancreatic insufficiency. However, phrynoderma can also develop if a patient follows a calorie-restricted diet (< 700 kcal/d) and strictly avoids vegetables, fruit and fats.

Health care providers should be attentive to the nutritional needs of patients at risk for malnutrition, including those who have been prescribed a strict weight-loss regimen and those who may be in a mal-absorptive state, such as patients who have undergone bariatric surgery. For these patients, health care providers should recommend diets, or at least supplements, that are rich in vitamins A, B, C and E, including foods such as yellow vegetables, green leafy vegetables, carrots, whole-milk derivatives, eggs, fish and oils (e.g., fish-liver oil, soybean oil, safflower oil, sunflower oil, corn oil, palm oil, cottonseed oil), as well as unprocessed cereal grains and nuts.

Many mild cases of hyperkeratosis phrynoderma may be overlooked, but if detected early, the underlying nutritional imbalances may be corrected.

BIOSKINTREATMENT is a skin regenerating lotion that prevents hyperkeratinization, reduces the appearance of new bumps and promises a blemish free complexion. This should be used twice a day, all week long.

Other Hyperkeratosis Disorders

Hyperkeratosis can also be a thickening of the outer layer of the skin. Our outer layer contains a tough, protective protein called keratin.

Skin thickening is often part of the skin’s normal protection against rubbing, pressure and other forms of local irritation. It causes calluses and corns on hands and feet. It can cause whitish areas inside the mouth.

Some of the forms of hyperkeratosis that occur as part of the skin’s defense are against:

  • Chronic (long-lasting) inflammation
  • Infection
  • Radiation of sunlight
  • Irritating chemicals

Less often, hyperkeratosis develops on skin that has not been irritated. These types of hyperkeratosis may be part of an inherited condition. They may begin soon after birth and can affect skin on large areas of the body.

There are many examples of hyperkeratosis. They include:

Corns and calluses. Corns and calluses develop in areas of skin exposed to repeated friction or pressure. In response, thick layers of dead skin cells pile up and harden.

Corns usually develop on irritated toes. Calluses form on the soles of the feet and the palms of the hands.

For many people, corns and calluses are simply a cosmetic nuisance. But for others, they are a painful and troublesome medical problem.

Warts. Warts are small bumps on the skin that are caused by human papilloma virus (HPV) infection. Plantar warts grow on the soles of the feet.

HPV usually is spread by direct contact. It is typically spread by touching or shaking hands with someone who already has a wart. It may also be spread by coming in contact with a contaminated surface. For example, by walking barefoot on a gym floor or a pool deck or by wearing someone else’s shoes.

Chronic eczema. Eczema is an inflammation of the skin. It can be triggered by allergies, irritating chemicals and other factors. Eczema is also called dermatitis.

Eczema causes itching, redness and tiny blisters. When the inflammation is difficult to control, chronic eczema can lead to:

  • Hyperkeratosis
  • Dry skin
  • Scaling
  • Changes in skin color
  • Localized hair loss

Lichen planus. This condition may appear as a lacy white patch on the inside of the mouth. Or it may be an itchy, violet, scaly patch elsewhere on the skin. Lichen planus may be related to an abnormal reaction of the immune system.

Actinic keratoses. These are flat, red, rough, sandpaper-like spots or patches of skin. They can be as tiny as a few millimeters.

They are caused by excessive exposure to the ultraviolet radiation of sunlight. They occur on sun-exposed areas of skin. And they have the potential to develop into skin cancer.

Seborrheic keratoses. These are small, noncancerous skin growths. They can be tan, brown or black. They appear on the face, trunk, arms or legs. Seborrheic hyperkeratoses are very common. Their cause is a mystery.

Inherited conditions. Several inherited conditions cause hyperkeratosis. They cause a widespread, thick, platelike scaling of the skin. Symptoms begin either shortly after birth or during early childhood.

Hyperkeratosis Lotion

BIOSKINTREATMENT is a biological solution for keratosis pilaris.

The lotion is powered by a complex biological compound with enzymes that “digest” or breakdown the hard keratin plugs of the hair follicles and dissolve abnormal keratin and tissues, releasing their amino acids for the rebuilding of healthy tissues.

It boosts the production of glycosaminoglycans the water holding molecules in healthy skin. It contains copper peptides that speed skin recovery and antimicrobial peptides that control microbes. It addresses all the factors involved in keratosis pilaris, acne, inflammation, scars and skin blemishes.

The lotion also contains natural salicylic acid extracted from the Willow Bark Tree and softens scales, unclogs pores and acts as a biological activator of both the elimination of dead and damaged skin cells and the renewal of healthy cells.

50 grams = 1.76 oz $60.00

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Save at least 10% off price & save on domestic or world wide shipping costs
when you order more than one month’s supply.

With the use of BIOSKINTREATMENT for a month you may remain free of Keratosis for months and possibly years. Or you may need to repeat the treatment every 6 months.

BIOSKINTREATMENT grinds down keratosis scales and horny crusts through enzyme dissolution of keratin and hydrolysis of abnormal tissues, and prevents the growth of actinic keratosis scaly formations

  • Dissolves dead and dying cells on the topmost micron of skin (part of the outer layer that is no thicker than a sheet of paper, slowly and over a period of time)
  • Digests damaged cells and keratin plugs within the dermis by the action of biological enzymes
  • Stimulates the use of the aminoacids that the enzymes free and activates the fibroblast stem cells which favor the proliferation of new healthy connective tissues and all the structural elements of healthy skin
  • Stimulates the formation of the extracellular binding between cells, thus improving skin strength, cutting down on fragility.
  • Restores the capacity of the skin to remain hydrated by stimulating the biosynthesis of glycosaminoglycans and proteoglycans, the molecules that give skin its capacity to keep in moisture. This helps to thicken the dermis resulting in a lessening of sagging and less fine lines and wrinkles.
  • Neutralizes free radicals by the action of its potent antioxidants that also have an anti-inflammatory effect.
  • Inhibits microbiological activity of dangerous, pathogenic skin bacteria, including acne.
  • Regulates blood vessel formation and oxygenation within the capillaries in the skin contributing to its proper nourishment.
  • Regulates dermal fibroblast proliferation and excess collagen, and thus prevents and reduces abnormal scars such as keloid and hyperthropic scarring and slowly but consistently gets rid of ice-pick scars or pitted acne scars.

BIOSKINTREATMENT also treats the dry, scaly skin that is present when skin is affected by actinic keratosis or ichthyosis vulgaris by exfoliating and thus reducing keratin clogged pores. And it helps to remove ingrown hairs and treat folliculitis (barber’s itch)

BIOSKINTREATMENT LOTION clears skin of keratin bumps and regenerates healthy skin

The product is made with the same base as BIOSKINCARE plus Salix Nigra (Willow) Extract and Amorphophallus Konjac Root Powder for a more potent keratolytic effect that cleans the excess horny material of the skin by degrading keratin plugs and dissolving debris, damaged, abnormal and necrotic tissues. It decongests the skin as the enzymes in the snail serum and the natural salicylic acid in willow bark extract help to ‘digest’ all damaged structures into their amino-acid and other components, which also favors the regeneration of all the structural components of healthy skin.

It leaves your skin smooth, refreshed, soft and with use over a period of time it takes away keratosis pilaris, actinic keratosis scales, controls acne and reduces and even vanishes all types of skin blemishes: razor nicks and burns, roughness, blisters, scrapes, cuts, and the list can go on and on…


  • Clears Keratosis Pilaris
  • Supports Your Immune System
  • Prevents Keratosis Pilaris
  • Makes Keratosis Lesions Regress
  • No Side Effects
  • Heals Skin Quickly
  • Repairs Sun Damaged Skin
  • The Most Powerful Antioxidants
  • Moisturizes Deep Within The Skin
  • Money Back Guarantee


  • Distilled Water (solvent)
  • Peg-4 Olivate (emulsifier derived from Olive Oil)
  • Sorbitan Olivate from Olive Oil (moisturizer)
  • Squalane from Olive Oil (natural moisturizer and antioxidant)
  • Hyaluronic Acid (1% solution – moisturizer)
  • Biocutis® Serum: Helix Aspersa Müller Glycoconjugates
  • Salix Nigra (Willow) Extract
  • Modified Amorphophallus Konjac Root Powder
  • Glycerin (humectant)
  • SUPRAPEIN ™, a synergistic combination of botanical extracts that yields a natural preservative with a broad-spectrum of antimicrobial activity.


“The only solution to our daughter’s keratosis pilaris. She is very appreciative as we are.”

Steve DeMarte. North Carolina, USA

“Have been using the Cream for two weeks now and I already see a difference in my skin after being diagnosed with keratosis pilaris. Thank you.”

Margitta Pelton. Florida, USA

“Have been using the cream for two weeks now and I already see a difference in my skin after being diagnosed with keratosis pilaris. thank you”.

Margitta Pelton. Florida, USA

“Thank you! Thank you! Thank you! I just received your product and immediately put it on. Believe it or not, within 2 hrs my Keratosis Pilaris is almost gone on my arms!!!! I’ve tried many different products over the years and have always been disappointed (they either didn’t work at all or took forever to work and then stopped). I am absolutely amazed, thrilled, and elated thanks to your product! I really believe that it is worth its weight in gold! Thank you a 1000 times again.”

Kris Taylor. Boston, USA